Selective induction of interleukin-6 in mouse microglia by granulocyte-macrophage colony-stimulating factor
Identifieur interne : 001A14 ( Main/Exploration ); précédent : 001A13; suivant : 001A15Selective induction of interleukin-6 in mouse microglia by granulocyte-macrophage colony-stimulating factor
Auteurs : Akio Suzumura [Japon] ; Makoto Sawada [Japon] ; Tohru Marunouchi [Japon]Source :
- Brain Research [ 0006-8993 ] ; 1996.
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Abstract
Abstract: Astrocytes produce granulocyte/macrophage colony-stimulating factor (GM-CSF) and support the survival and proliferation of microglia. To study the functions of GM-CSF in the central nervous system (CNS), we examined the effects of GM-CSF on cytokine production by glial cells. GM-CSF induced interleukin-6 (IL-6) production by microglia, but not by astrocytes, in a dose-dependent manner as assessed by bioassay and the detection of IL-6 mRNA by reverse transcriptase-polymerase chain reaction (RT-PCR) analysis. GM-CSF did not induce tumor necrosis factor (TNF)a or IL-1 in microglia and astrocytes, whereas lipopolysaccharide induced all these cytokines. The induction of IL-6 by GM-CSF in microglia was completely inhibited by antibodies to GM-CSF. Neither IL-3 nor macrophage-CSF (M-CSF) induced IL-6 production in microglia. Given that IL-1 and TNFα, monokines derived from microglia, induce IL-6 production in astrocytes, but not in microglia, results indicate that astrocytes and microglia may mutually regulate IL-6 production by different cytokines.
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DOI: 10.1016/0006-8993(95)01535-3
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To study the functions of GM-CSF in the central nervous system (CNS), we examined the effects of GM-CSF on cytokine production by glial cells. GM-CSF induced interleukin-6 (IL-6) production by microglia, but not by astrocytes, in a dose-dependent manner as assessed by bioassay and the detection of IL-6 mRNA by reverse transcriptase-polymerase chain reaction (RT-PCR) analysis. GM-CSF did not induce tumor necrosis factor (TNF)a or IL-1 in microglia and astrocytes, whereas lipopolysaccharide induced all these cytokines. The induction of IL-6 by GM-CSF in microglia was completely inhibited by antibodies to GM-CSF. Neither IL-3 nor macrophage-CSF (M-CSF) induced IL-6 production in microglia. Given that IL-1 and TNFα, monokines derived from microglia, induce IL-6 production in astrocytes, but not in microglia, results indicate that astrocytes and microglia may mutually regulate IL-6 production by different cytokines.</div></front></TEI><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Suzumura, Akio" sort="Suzumura, Akio" uniqKey="Suzumura A" first="Akio" last="Suzumura">Akio Suzumura</name></noRegion><name sortKey="Marunouchi, Tohru" sort="Marunouchi, Tohru" uniqKey="Marunouchi T" first="Tohru" last="Marunouchi">Tohru Marunouchi</name><name sortKey="Sawada, Makoto" sort="Sawada, Makoto" uniqKey="Sawada M" first="Makoto" last="Sawada">Makoto Sawada</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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